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Discrete diffusion models have been limited to simplistic noising schemes like uniform corruption or masking, restricting their ability to leverage semantic structure in large vocabularies. This paper introduces GDDS (Generalized Discrete Diffusion from Snapshots), a framework supporting arbitrary continuous-time Markov chain noising processes via exact uniformization-based sampling and a tractable snapshot-level ELBO. The work achieves state-of-the-art results on large-scale language modeling tasks, claiming to surpass autoregressive baselines for the first time at this scale.
Domain Elastic Transform (DET) addresses the registration of high-dimensional vector-valued functions on irregular, sparse manifolds—a critical bottleneck in spatial transcriptomics where gene expression data resides on scattered cell positions rather than regular grids. The core idea is a Bayesian framework that treats registration as elastic domain deformation guided by a joint spatial-functional likelihood, bypassing the lossy voxelization required by image-based methods while exploiting functional signals that pure geometric point-set registration ignores. This matters because it enables training-free analysis of massive atlases (e.g., MERFISH, Stereo-seq) without sacrificing single-cell resolution.